2024 NFL Week 1 odds, predictions, picks, lines for all 16 games

NFL bettors — start your betting engines. 

With Week 1 of the 2024-25 NFL season officially here, game lines are out and on the move. 

The biggest Week 1 games are the showdowns between the Chiefs and Ravens on Thursday night, and the Cowboys and Browns on Sunday (FOX and the FOX Sports app).

Last season, America’s Team clinched a playoff berth after notching a 12-5 regular season record. Dallas faced Green Bay in the NFC wild card round and lost 48-32. 

The Browns also lost in the wild-card round last season when they fell to the Texans 45-14. However, by most standards, Cleveland overachieved in 2023 by making it to the playoffs with quarterback Joe Flacco at the helm and a host of injuries throughout its roster.

As for Kansas City, it won its second consecutive Super Bowl, knocking off Baltimore in the AFC title game.

Check out the lines for all 16 NFL games at DraftKings Sportsbook, as well as some early best bets from Geoff Schwartz. 

(All times ET)

2024 NFL Week 1 Odds and Predictions

SUNDAY, SEPT. 8

PITTSBURGH STEELERS @ ATLANTA FALCONS (1 p.m., FOX and FOX Sports app)

Point spread: Falcons -3.5 (Falcons favored to win by 4 points or more, otherwise Steelers cover)
Moneyline: Falcons -170 favorites to win (bet $10 to win $15.88 total); Steelers +142 underdogs to win (bet $10 to win $24.20 total)
Total scoring Over/Under: 41 points scored by both teams combined

ARIZONA CARDINALS @ BUFFALO BILLS (1 p.m., CBS)

Point spread: Bills -6.5 (Bills favored to win by 7 points or more, otherwise Cardinals cover)
Moneyline: Bills -325 favorites to win (bet $10 to win $13.08 total); Cardinals +260 underdogs to win (bet $10 to win $36 total)
Total scoring Over/Under: 47 points scored by both teams combined

TENNESSEE TITANS @ CHICAGO BEARS (1 p.m., FOX and FOX Sports app)

Point spread: Bears -3.5 (Bears favored to win 4 points or more, otherwise Titans cover)
Moneyline: Bears -185 favorites to win (bet $10 to win $15.41 total); Titans +154 underdogs to win (bet $10 to win $25.40 total)
Total scoring Over/Under: 44.5 points scored by both teams combined

NEW ENGLAND PATRIOTS @ CINCINNATI BENGALS (1 p.m., CBS)

Point spread: Bengals -7.5 (Bengals favored to win by 9 points or more, otherwise Patriots cover)
Moneyline: Bengals -395 favorites to win (bet $10 to win $12.53 total); Patriots +310 underdogs to win (bet $10 to win $41 total)
Total scoring Over/Under: 41 points scored by both teams combined

JACKSONVILLE JAGUARS @ MIAMI DOLPHINS (1 p.m., CBS)

Point spread: Dolphins -3.5 (Dolphins favored to win by 4 points or more, otherwise Jaguars cover)
Moneyline: Dolphins -162 favorites to win (bet $10 to win $16.17 total); Jaguars +136 underdogs to win (bet $10 to win $23.60 total)
Total scoring Over/Under: 49.5 points scored by both teams combined

HOUSTON TEXANS @ INDIANAPOLIS COLTS (1 p.m., CBS)

Point spread: Texans -3 (Texans favored to win by 3 points or more, otherwise Colts cover)
Moneyline: Texans -148 favorites to win (bet $10 to win $16.76 total); Colts +124 underdogs to win (bet $10 to win $22.40 total)
Total scoring Over/Under: 48.5 points scored by both teams combined

CAROLINA PANTHERS @ NEW ORLEANS SAINTS (1 p.m., FOX and FOX Sports app)

Point spread: Saints -4 (Saints favored to win by more than 4 points, otherwise Panthers cover)
Moneyline: Saints -192 favorites to win (bet $10 to win $15.21 total); Panthers +160 underdogs to win (bet $10 to win $26 total)
Total scoring Over/Under: 41.5 points scored by both teams combined

MINNESOTA VIKINGS @ NEW YORK GIANTS (1 p.m., FOX and FOX Sports app)

Point spread: Vikings -1.5 (Vikings favored to win by 2 points or more, otherwise Giants cover)
Moneyline: Vikings -122 favorites to win (bet $10 to win $18.20 total); Giants +102 underdogs to win (bet $10 to win $20.20 total)
Total scoring Over/Under: 41 points scored by both teams combined

LAS VEGAS RAIDERS @ LOS ANGELES CHARGERS (4:05 p.m., CBS)

Point spread: Chargers -3 (Chargers favored to win by more than 3 points, otherwise Raiders cover)
Moneyline: Chargers -155 favorites to win (bet $10 to win $16.45 total); Raiders +130 underdogs to win (bet $10 to win $23 total)
Total scoring Over/Under: 40 points scored by both teams combined

DENVER BRONCOS @ SEATTLE SEAHAWKS (4:05 p.m., CBS)

Point spread: Seahawks -6 (Seahawks favored to win by more than 6 points, otherwise Broncos cover)
Moneyline: Seahawks -245 favorites to win (bet $10 to win $14.08 total); Broncos +200 underdogs to win (bet $10 to win $30 total)
Total scoring Over/Under: 41.5 points scored by both teams combined

DALLAS COWBOYS @ CLEVELAND BROWNS (4:25 p.m., FOX and FOX Sports app)

Point spread: Browns -2.5 (Browns favored to win by 3 points or more, otherwise Cowboys cover)
Moneyline: Browns -135 favorites to win (bet $10 to win $17.41 total); Cowboys +114 underdogs to win (bet $10 to win $21.40 total)
Total scoring Over/Under: 41 points scored by both teams combined

Pick by Geoff Schwartz:

I have the Browns winning and covering against the Cowboys because of the line of scrimmage. The Cowboys will be starting two rookie offensive linemen in their first road start against the Browns defensive line. Myles Garrett — one of the best defensive players in the game — is going to pass rush against Tyler Guyton, a rookie left tackle who needs polish in the NFL. The Cowboys will struggle to rush the ball and Dak Prescott will get hit all game. It’s worrisome for me. 

On the other side of the ball, the Browns will have a healthy offensive line for Week 1. Although losing offensive line coach Bill Callahan isn’t ideal for development, they have a veteran group, and they added Jerry Jeudy to the skill group. The Cowboys lost defensive coordinator Dan Quinn to the Commanders, and they are due for a regression this season on defense. I’m wagering that regression starts right away.

PICK: Browns (-1 at time of pick) to win by more than 1 point

WASHINGTON COMMANDERS @ TAMPA BAY BUCCANEERS (4:25 p.m., FOX and FOX Sports app)

Point spread: Bucs -3.5 (Bucs favored to win by more than 3 points, otherwise Commanders cover)
Moneyline: Bucs -170 favorites to win (bet $10 to win $15.88 total); Commanders +142 underdogs to win (bet $10 to win $24.20 total)
Total scoring Over/Under: 42.5 points scored by both teams combined

Pick by Geoff Schwartz:

Once Baker Mayfield replaced Tom Brady at quarterback, most people wrote Tampa Bay off. But as we know, the Bucs went on to win the NFC South and host a playoff game. Mayfield had a career resurgence last season and Tampa Bay is poised to compete once again for a playoff berth. The Commanders are rolling into town for a Week 1 matchup with a rookie quarterback and a questionable offensive line. Feels like a recipe for a tough matchup against Todd Bowles’ defense. The Commanders are rebuilding their exterior pass rush and have added new pieces in the back end of the defense. I do believe Dan Quinn will get this unit going, but probably not right away. I like the Bucs to cover.

PICK: Buccaneers (-3.5 at time of pick) to win by 4 points or more

LOS ANGELES RAMS @ DETROIT LIONS (8:20 p.m., NBC)

Point spread: Lions -4.5 (Lions favored to win by 4 points or more, otherwise Rams cover)
Moneyline: Lions -170 favorites to win (bet $10 to win $15.88 total); Rams +142 underdogs to win (bet $10 to win $24.20 total)
Total scoring Over/Under: 52 points scored by both teams combined

MONDAY, SEPT. 9

NEW YORK JETS @ SAN FRANCISCO 49ERS

Point spread: 49ers -4.5 (49ers favored to win by 5 points or more, otherwise Jets cover)
Moneyline: 49ers -218 favorites to win (bet $10 to win $14.59 total); Jets +180 underdogs to win (bet $10 to win $28 total)
Total scoring Over/Under: 43.5 points scored by both teams combined

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, and follow leagues, teams and players to receive a personalized newsletter daily!

---

---